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The Song of the Cell

4/5. Very good medical history and topic exploration under the broad umbrella of cellular biology. A lot of expected things here – IVF, cancer – but also some surprises and his usual elegance and humanism. Ignore the subtitle, it’s dumb publisher irrelevance.
lightreads: a partial image of a etymology tree for the Indo-European word 'leuk done in white neon on black'; in the lower left is (Default)
The Gene: An Intimate History

5/5. This book is a doorstop, but worth every page. It covers a huge amount of ground – from Mendel and his pea plants to Carrie Buck to Rosalind Franklin to the ethics of recombinant DNA to the just-last-year reality of actual live genetic therapies approved for use in the U.S. With several pauses along the way to discuss the author's family and the strain of hereditary illness criss-crossing it.

It's no mystery why I'm reading this now. I believe that our genes make us who we are far more strongly than many people are comfortable admitting. This has been becoming even clearer to me as the baby who owes her existence to an egg I donated grows up and, without having interacted with me more than once a year or so for her entire life, continues to be eerily like me, down to the pathologically strong terror of strangers developed at the exact same age and fading at the exact same age. (She looks like me too, but that's way less interesting). I dearly wish a lot of straight, fertile couples would have the strange experience of having to go to a sperm bank or an egg bank and pick someone out. It sharpens the mind in a way that I think is salutary, if uncomfortable. Makes you articulate what you want in a child in a cold-blooded way. Makes you state your values in people as commodities.

And, well, the other thing. I mentioned up there the newly-approved – as in less than a year ago – genetic therapy. Yeah. The first genetic therapy approved in the U.S. is for my primary disability. It may not work on me – actually, the odds are strong it will not. And the fact I haven't done much about it until now probably tells you a lot about my feelings on the matter. But I do need to know, eventually. Will I get an injection that rewrites the protein-encoding DNA in my optic nerve and improve my acuity up to 1000%? Probably not this shot, the mutation prevalence breakdowns tell me. But another shot ten years from now? Yeah, that is a real thing I'm going to have to really deal with, it seems like.

So naturally I read a book about it. One of many to come, I suspect.
lightreads: a partial image of a etymology tree for the Indo-European word 'leuk done in white neon on black'; in the lower left is (Default)
The Emperor of All MaladiesThe Emperor of All Maladies by Siddhartha Mukherjee

My rating: 4 of 5 stars


Excellent. And exactly as a friend described it – "exhaustive, exhausting." This is pitched perfectly for me, the well-educated not-a-doctor. And like the very best nonfiction, this book is clearly written from a place of deep passion for the subject. He has the exact right balance here between cool, researcher's zeal, and human grasp of the "charring, personal war" each of his patients is fighting. This book made me tired and sad and amazed and hopeful and scared, and then everything all at once.

I've been reading a lot about cancer this year. I realized this just a minute ago, flipping back through reviews. Post processing, probably. But funnily enough, I wasn't thinking about my girlfriend while I was reading this. I don't know, for her, treatment was a series of gates to enter, pre-set paths to walk, tokens to collect. Have this surgery, starve yourself for a month, get irradiated in this precise way, do it again, do it again – no wait, psych, don't. It was like being passed from one set of highly competent hands to another and another in a baton race – everyone seemed to know exactly what ought to come next. This book isn't about those kinds of fights, as much.

Mostly I thought about B. How we used to sit together on my patio at night, knee-to-knee on the cement. Our guide dogs would curl up in front of us, tucked back-to-back, my sleek, creamy, fierce little girl lab and his giant, silly, shaggy black lab. He had retinal blastoma as a baby. They took out both eyes. I was only eight months out from my last eye surgery, I still have both eyes, but at that point it was more likely that I wouldn't, always. He talked me through his prosthetics, let me touch them, told me how one eye still hurt even though the doctors said it shouldn't. He was a drummer and a bit of a stoner; he wrote me strange emails sometimes in the middle of the night. He died before his twenty-third birthday. It took the cancer twenty years to catch up, but it got him.

This book is about his kind of cancer. His specific disease type, but also more broadly the type of cancer that becomes a companion. A lifelong companion, for however long life is. The kind that requires enormous creativity, endurance, brutality.

It's a very, very good book.




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