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Life's Edge

3/5. Brief nonfiction tour of scenarios that uncomfortably challenge the lay and scientific consensus on what it means to be alive. To the extent there is consensus, which is not as much as you'd think. Hits the obvious ones early on – gametes and also people declared brain dead in long-term comas on life support – then swings through a succession of weird cellular and animal examples. Interesting, but not going to blow your mind open if you've spent even a small amount of time reading in biology or medicine.
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She Has Her Mother's Laugh: The Powers, Perversions, and Potential of Heredity

4/5. Quick, everyone write your erudite yet personal doorstops on genetics! It's apparently what one does now. Luckily, there's a lot to say; this book has remarkably little to no overlap with Mukherjee's, which came out around the same time.

I read this over a . . . complicated few weeks in March while waiting to find out if my 2 in one hundred thousand diagnosis is the 1 in 1.25 million that is now treatable (it's not – don't say your sorry, it's based in ableist assumptions about what I was going to do with this information, and your ableist assumptions are quite possibly wrong) and also while waiting for the amnio results that would likely decide whether my pregnancy is ending in a live birth or not (baby is absolutely fine, exhale, it's okay).* So yeah, an interesting few weeks to be reading about the applications and misapplications of genetics.

It's a good book; less technical than mukherjee's in a lot of ways, and also a bit less philosophical, but with fascinating diversions into mosaicism and how we could probably wipe out mosquito-born malaria in a few years if it weren't so terrifying and possibly unethical. I do have to say that the author is pretty interested in his personal genome which, fair enough. But I've come to realize that listening to someone else talk about their genes is about as interesting as listening to someone else talk about their dreams. Which is to say, 90% of the time, it's of great significance to the speaker and absolutely none to anyone else in the world. Seriously, have you ever had to sit through someone recounting in excruciating detail what percentage of which part of their heritage comes from different parts of Europe? No one cares but you! In the 10% of really interesting discussions might be this fascinating story, which is of course interesting because it only starts with genetics but has to do with so much more.

*Oh yeah, that. Yeah. I'm due at the end of the summer. :D
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It’s impossible to talk about the history of the brain – about the history of medicine at large, actually – without also talking about religion and politics and philosophy. Mostly religion, as you might expect. This book tackles all of the above with admirable aplomb, starting off with one of my favorite childhood anecdotes about the ancient Egyptian burial custom of removing the brain through the nostrils because it was clearly a useless organ (how can you not love that; it’s totally disgusting!). We hop on through the first anatomists, sojourn a bit with alchemy, pause for natural philosophy, and then settle down in fifteenth-century England for the majority of the book. This is a bit too broad to be classified as a biography of Thomas Willis (the father of neuroscience), but it’s a close thing. It’s a thorough, ranging but focused account of the history of the brain and how we conceive of our conscious minds, our souls, ourselves as animals. And a whole lot of familiar names keep popping up, like Hobbes and Locke (a doctor, which I had forgotten) and the two Roberts (Boyle and Hooke) who are better known for their work in physics and chemistry, but who actually made enormous contributions to the understanding of human respiration and blood oxygenation.

Well-researched, entirely lucid, a bit rambling but in the good way. There’s a whole hell of a lot of ground to cover when you start out before we even realized the brain was the seat of consciousness, not to mention the many theologians and anatomists alike who maintained the soul by its nature could not be physical. This book covers most of that very well, particularly in detailing the ebb and flow of experimentation through England’s revolution and restoration. I was unsatisfied by the sudden 350 year leap made in the last chapter, and the rushed treatment of modern nuropharmacology and the potential of MRI studies (what is the brain doing when confronted with some of those awful moral philosophy questions – in situation x you can save five people by killing one, what do you do?). I honestly would have been happier had the book simply maintained its historical focus and stopped in the fifteenth century. Which would have left the “and how it changed the world” part mostly to inference, but I almost would have preferred inference to the rushed and vague cap on an otherwise nuanced account. The writing here is also rather dry. It’s not bad by any stretch of the imagination – it’s more invisible than anything – and I’m spoiled by the last nonfiction I read. Still, it’s a consideration.

On balance, this is definitely a book you will like if you like that sort of thing. Otherwise it will be deeply dull. Luckily, I like that sort of thing.

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